Thermo Fisher Scientific Phospho-PDPK1 (Tyr376) Polyclonal Antibody
PDPK1 Tyr376 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합. 인간, 생쥐, 랫트 반응성. 고순도 정제 및 안정적 액상 형태로 제공. 연구용 전용.
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PDPK1 (Tyr376) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:3,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDPK1 (Accession O15530), corresponding to amino acid residues around phosphorylated Tyr376 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817258 |
Product Specific Information
This antibody detects endogenous levels of PDPK1 only when phosphorylated at Tyr376.
Target Information
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to dephosphorylation and activation of glycogen synthase and stimulation of glycogen synthesis.
Given its role in insulin-induced glycogen synthesis and PKC activation, PDPK1 is an important target for metabolic drug research.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-105859_PDPK1_O15530-1_Rabbit.svg, PA5-105859_PDPK1_O15530-1_Rabbit_PDP.jpeg)
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