Thermo Fisher Scientific Phospho-Met (Ser985) Polyclonal Antibody
Phospho-Met (Ser985) 항체로 인산화된 c-Met 단백질 검출에 적합. Western blot 및 ICC/IF에 사용 가능. 사람, 생쥐, 랫트 반응성. 고순도 rabbit polyclonal 항체로 1 mg/mL 농도. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MET (Accession P08581), corresponding to amino acid residues around phosphorylated Ser985. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817256 |
Product Specific Information
This antibody detects endogenous levels of c-Met only when phosphorylated at Ser985.
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC. MET is involved in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and in adult processes including wound healing, organ regeneration, and tissue remodeling. Aberrant MET signaling is associated with cancers such as gastric, renal, and breast cancers, making it a key target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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