Thermo Fisher Scientific Phospho-Met (Tyr1235) Polyclonal Antibody
c-Met의 Tyr1235 잔기에서 인산화된 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 ICC/IF에 적합하며, 인간, 마우스, 랫트 시료에 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MET (Accession P08581), corresponding to amino acid residues around phosphorylated Tyr1235. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817255 |
Product Specific Information
This antibody detects endogenous levels of c-Met only when phosphorylated at Tyr1235.
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions activate signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET plays critical roles in embryonic development such as gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling. Dysregulation of MET has been associated with cancers including gastric, renal, and breast cancer, making it an important target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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