Thermo Fisher Scientific Human ICAM-1 (CD54) Recombinant Protein, eBioscience
CHO 세포에서 발현된 Human ICAM-1 재조합 단백질로, 천연 순환형 ICAM-1 구조를 모방. SDS-PAGE 기준 99% 이상 고순도. ELISA, Flow Cytometry 등 다양한 실험에 활용 가능. -20°C 보관, PBS 용액 내 무방부제 상태로 공급.
- 카탈로그번호
- BMS313
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-Dependent
ELISA (ELISA)
- Tested Dilution: Assay-Dependent
Control (Ctrl)
- Tested Dilution: Assay-Dependent
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Not Applicable |
| Expression System | CHO cells |
| Amino Acid Sequence | Human ICAM-1 recombinant protein truncated at the ectodomain side of the beginning of the transmembrane region (472 amino acids) |
| Molecular Weight | 82 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >99% by SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Product Specific Information
Recombinant soluble ICAM-1 is produced in CHO cells and corresponds in structure with natural human circulating ICAM-1, truncated at the ectodomain side of the beginning of the transmembrane region (aa.472).
BMS313 is >99% pure as demonstrated by SDS-gel electrophoresis.
Purity: >99%.
Molecular Weight: 82.0 kDa.
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region, and a cytoplasmic domain.
ICAM-1 has seven potential N-linked glycosylation sites and shares amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102).
It binds to integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) and also serves as a receptor for Rhinovirus.
ICAM-1 is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, B and T lymphocytes (low), monocytes, macrophages, dendritic cells, and neutrophils. Expression increases upon inflammation and is also observed in certain carcinoma and melanoma cells.
Soluble ICAM-1 is detectable in plasma and elevated in various inflammatory syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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