Thermo Fisher Scientific Annexin V Recombinant Protein, FITC, eBioscience
FITC로 표지된 Annexin V 재조합 단백질로, 세포 사멸(apoptosis) 단계 구분에 사용. E. coli 발현 시스템에서 제조되었으며, >89% 순도 보유. Flow Cytometry 분석에 적합하며, 4°C에서 암조건 보관. 연구용으로만 사용 가능.
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Applications
Flow Cytometry (Flow)
- Assay-Dependent
Control (Ctrl)
- Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | All, Human, Mouse, Rat |
| Expression System | E. coli |
| Class | Recombinant |
| Type | Protein |
| Purity | >89% by SDS-PAGE and RP-HPLC |
| Conjugate | FITC |
| Excitation/Emission Max | 498/517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Purified |
| Storage Buffer | TBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Wet ice |
Product Specific Information
Annexins are a family of calcium-dependent phospholipid-binding proteins that bind to phosphatidylserine (PS) to identify apoptotic cells. In healthy cells, PS is located on the cytosolic side of the plasma membrane. During apoptosis, PS translocates to the extracellular side, which can be detected with fluorescently labeled Annexin V.
In early apoptosis, cells stained only with Annexin V (PI/7-AAD negative) are viable but undergoing apoptosis. In late apoptosis, loss of membrane integrity allows both Annexin V binding and uptake of PI or 7-AAD. Annexin V staining combined with PI or 7-AAD is widely used in flow cytometry to distinguish apoptotic stages.
Annexin V also functions as an anticoagulant protein by inhibiting prothrombin activation. Antibodies to Annexin V are associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions, and systemic sclerosis (SSc).
Purity: Annexin V is >89% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
FITC labeling enables direct detection of PS by FACS analysis. Counterstaining with propidium iodide allows discrimination of apoptotic cells.
Target Information
The gene encoding Annexin V belongs to the annexin family of calcium-dependent phospholipid-binding proteins. These proteins are involved in membrane events related to exocytosis and endocytosis. Annexin V acts as a phospholipase A2 and protein kinase C inhibitory protein, with calcium channel activity and potential roles in signal transduction, inflammation, growth, and differentiation.
Annexin V is also known as:
- Placental anticoagulant protein I
- Vascular anticoagulant-alpha
- Endonexin II
- Lipocortin V
- Placental protein 4
- Anchorin CII
The gene spans approximately 29 kb, containing 13 exons, encoding a 1.6 kb transcript and a protein of about 35 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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