Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (DO-1)
인간 p53 종양억제 단백질을 인식하는 단일클론 항체로 다양한 응용(WB, IHC, Flow 등)에 사용 가능. DO-1 클론, Mouse IgG2a, kappa. 고순도 Protein A/G 정제, 액상 형태로 4°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (DO-1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DO-1 |
| Immunogen | Recombinant human wild type p53 protein expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Monkey or Rat.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon stress, p53 upregulates transcription of genes such as p21waf1, leading to G1 or G2/M arrest.
Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 also relates to aging, oxidative stress, and cognitive functions such as long-term potentiation (LTP). It is expressed at low levels in normal cells but highly in transformed cell lines, contributing to malignancy. Mutations in TP53 cause loss of tumor suppressor activity and are linked to various human cancers, including Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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