Thermo Fisher Scientific SHANK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (IHC)

1:100-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SHANK1,uniProtId:Q9WV48-1,ncbiNodeId:10114,antigenRange:1951-1964,antigenLength:2167,antigenImageFileName:PA1-4180_SHANK1_Q9WV48-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4180_SHANK1_Q9WV48-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2187592

Product Specific Information

PA1-4180 detects SHANK1a in human, rat, and mouse samples.

PA1-4180 has been successfully used in Western blot, immunofluorescence, and immunofluoresence procedures. By Western blot this antibody detects a ~212 kDa protein representing SHANK1a in rat brain lysate.

The PA1-4180 immunogen is a synthetic peptide corresponding to the C-terminal residues S(1951) G P I Y P G L F D I R S S(1964) of rat Shank1a.

Maintain at 4ºC for 3 months or at -20ºC for longer periods. Avoid freeze/thaw cycles.

Target Information

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.