Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (mab636)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA3-1000 detects lamin A/C from human, bovine, porcine, and canine samples.
It has been successfully used in Western blot, immunofluorescence, and immunohistochemistry procedures.
By Western blot, this antibody detects approximately 70 and 65 kDa proteins corresponding to lamin A and C, respectively, from HeLa cell extract.
It is also useful for subcellular localization experiments and has been widely used for detection of lamin A/C control in siRNA experiments.
The MA3-1000 antigen is a porcine lamin preparation.

Target Information

Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope.
They exist in several forms (A, B, and C), with lamins A and C being alternatively spliced products of the LMNA gene.
Mutations in LMNA are associated with various disorders, including:

• Emery-Dreifuss muscular dystrophy
• Dunnigan-type familial partial lipodystrophy (FPLD)
• Limb-girdle muscular dystrophy (LGMD1B)
• Dilated cardiomyopathy (CMD1A)
• Axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1)
• Mandibuloacral dysplasia (MAD)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.