Thermo Fisher Scientific Lamin A/C Monoclonal Antibody (mab636)
Lamin A/C 단백질을 인식하는 Thermo Fisher monoclonal antibody (mab636). Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능. 인간, 소, 돼지 등에서 반응하며, Protein A 정제 및 PBS/BSA buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:2,000 | View 15 publications |
| Immunohistochemistry (IHC) | – | View 5 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100 | – |
| Immunocytochemistry (ICC/IF) | 1:100 | View 11 publications |
| Flow Cytometry (Flow) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Pig |
| Published Species | Human, Mouse, Pig |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | mab636 |
| Immunogen | Porcine lamin preparation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_325377 |
Product Specific Information
MA3-1000 detects lamin A/C from human, bovine, porcine, and canine samples.
It has been successfully used in Western blot, immunofluorescence, and immunohistochemistry procedures.
By Western blot, this antibody detects approximately 70 and 65 kDa proteins corresponding to lamin A and C, respectively, from HeLa cell extract.
It is also useful for subcellular localization experiments and has been widely used for detection of lamin A/C control in siRNA experiments.
The MA3-1000 antigen is a porcine lamin preparation.
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope.
They exist in several forms (A, B, and C), with lamins A and C being alternatively spliced products of the LMNA gene.
Mutations in LMNA are associated with various disorders, including:
- Emery-Dreifuss muscular dystrophy
- Dunnigan-type familial partial lipodystrophy (FPLD)
- Limb-girdle muscular dystrophy (LGMD1B)
- Dilated cardiomyopathy (CMD1A)
- Axonal neuropathy (Charcot-Marie-Tooth disease; CMT2B1)
- Mandibuloacral dysplasia (MAD)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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