Thermo Fisher Scientific CD31 Monoclonal Antibody (2H8)

Applications and Publications

Product Specifications

Product Specific Information

MA3105 targets CD31 in FACS and neutralization applications and shows reactivity with mouse and human samples.
The immunogen is mouse PECAM-1 (CD31).
MA3105 detects CD31 with a predicted molecular weight of approximately 79 kDa.
This product has been tested for endotoxins by limulus amoebocyte lysate (LAL) assay and contains ≤10 EU/mg endotoxin concentration.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through dual immunoreceptor tyrosine-based inhibitory motifs (ITIM). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed throughout the vascular compartment, mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, facilitating cell-cell interactions.
CD31 plays key roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis.
It is one of the key regulatory molecules in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.