Thermo Fisher Scientific HSPB8 Monoclonal Antibody (3C12-H11), PerCP

Applications and Tested Dilutions

Product Specifications

Available Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

1 µg/mL of MA5-45255 was sufficient for detection of HSP22 in 20 µg of whole rat tissue extract by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 22 kDa. Detects endogenous and exogenous HSP22 in monomeric, dimeric, and tetrameric forms in WB. Does not cross-react with alpha crystallin.

Target Information

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conserved alpha-crystallin domain at the C-terminal part of the molecule.
Expression of this gene is induced by estrogen in estrogen receptor-positive breast cancer cells. This protein functions as a chaperone in association with Bag3, a stimulator of macroautophagy.
It is involved in regulation of cell proliferation, apoptosis, and carcinogenesis. Mutations in this gene have been associated with neuromuscular diseases, including Charcot-Marie-Tooth disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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