Thermo Fisher Scientific HIF-1 alpha Monoclonal Antibody (ESEE122), APC
HIF-1 alpha 단백질 검출용 APC 결합 단일클론 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫트 등 반응성 보유. 고순도 Protein G 정제, 보존제 없음. 저산소 반응 연구 및 종양 생물학 연구에 유용.
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Thermo Fisher Scientific HIF-1 alpha Monoclonal Antibody (ESEE122), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESEE122 |
| Immunogen | Recombinant fragment corresponding to amino acids 329–530 of HIF1A |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.46mM phosphate / 2.48mM MES, pH 7.4, with 2mM EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931704 |
Additional Formats
- FITC (Cat. MA5-45251)
- PerCP (Cat. MA5-45252)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45250 was sufficient for detection of HIF1 alpha in 20 µg of CoCl₂-induced HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 116 kDa. Specific for HIF1-alpha.
Target Information
HIF1-alpha (HIF1A) is a subunit of HIF1, a transcription factor found in mammalian cells under hypoxic conditions. HIF1 is a heterodimer composed of alpha and beta subunits, both belonging to the PAS family of transcription factors.
Under hypoxia, HIF1 activates transcription of over 40 genes involved in oxygen delivery and metabolic adaptation, including erythropoietin, glucose transporters, glycolytic enzymes, and VEGF.
HIF1-alpha also regulates hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis. It interacts with p53 and MDM2 under hypoxic conditions, influencing protein degradation.
In humans, HIF1A is located on chromosome 14q and binds to p300/CBP to induce hypoxia-responsive genes such as VEGF.
Hypoxia contributes to the pathophysiology of diseases including ischemia, cancer, pulmonary hypertension, and chronic obstructive pulmonary disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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