Thermo Fisher Scientific P16INK4a Monoclonal Antibody (rCDKN2A/7659)
인간 p16INK4a 단백질을 인식하는 Mouse monoclonal 항체. Western blot 및 IHC(P, PFA) 분석에 적합. Protein A/G로 정제된 액상 제품으로 4°C 보관. 세포주기 조절 및 종양 억제 연구에 활용 가능.
- 카탈로그번호
- 1029-MSM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific P16INK4a Monoclonal Antibody (rCDKN2A/7659)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCDKN2A/7659 |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms functioning as inhibitors of CDK4 kinase.
Another transcript includes an alternate first exon located 20 Kb upstream, containing an alternate open reading frame (ARF) that encodes a structurally unrelated protein. This ARF product stabilizes the tumor suppressor protein p53 by interacting with and sequestering the E3 ubiquitin-protein ligase MDM2, preventing p53 degradation.
Despite structural and functional differences, the CDK inhibitor isoforms and the ARF product share a common role in regulating cell cycle G1 progression via CDK4 and p53 pathways.
Mutations or deletions in this gene are frequent in various tumors, highlighting its importance as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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