Thermo Fisher Scientific P16INK4a Monoclonal Antibody (rCDKN2A/7659)
인간 p16INK4a 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P, PFA) 분석에 사용됩니다. Protein A/G로 정제된 액상 형태이며, PBS(pH 7.4) 버퍼에 보존제 없이 제공됩니다. 세포주기 조절 및 종양 억제 연구에 적합합니다.
- 카탈로그번호
- 1029-MSM9-P1ABX
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCDKN2A/7659 |
| Immunogen | Purified recombinant prokaryotic full-length human p16INK4a protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CDKN2A (p16INK4a) gene produces several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which act as CDK4 kinase inhibitors. Another variant encodes an alternate open reading frame (ARF) that stabilizes the tumor suppressor protein p53 by interacting with and sequestering MDM2, an E3 ubiquitin-protein ligase responsible for p53 degradation.
Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product contribute to cell cycle G1 control through regulation of CDK4 and p53.
Mutations or deletions in this gene are common in various tumors, marking it as a key tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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