Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (17B5), APC, eBioscience
마우스 CD137(4-1BB) 인식용 단클론 항체로, APC 형광체가 결합된 제품입니다. 활성화된 T 세포 표면의 CD137 검출에 사용되며, 유세포 분석에 최적화되어 있습니다. 0.25 µg/test로 사용 가능하며, 4°C 암소 보관이 권장됩니다.
- 카탈로그번호
- 17-1371-8x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (17B5), APC, eBioscience
Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (17B5), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 0.25 µg/test | View 7 publications |
| Functional Assay (Functional) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Syrian hamster / IgG |
| Recommended Isotype Control | Syrian Hamster IgG Isotype Control, APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17B5 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573161 |
Additional Formats
- Biotin
- eFluor 450
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The 17B5 monoclonal antibody reacts with mouse CD137 (4-1BB), a member of the TNFR superfamily. CD137 is expressed on activated T cells as monomers, dimers, and tetramers around day 4–6 after activation through the TCR complex. Interaction with its ligand, 4-1BBL, delivers a costimulatory signal crucial for T-APC interaction.
Recent data suggests CD137 is expressed on Tregs and may play a role in their proliferation. The 17B5 antibody exhibits strong antagonistic activity in functional assays.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Tested on stimulated mouse splenocytes; use ≤ 0.25 µg per test (100 µL final volume). Optimize antibody titration for best results.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD137 (TNFRSF9, 4-1BB) is an inducible costimulatory molecule mainly expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitors.
CD137 signaling maintains activated and memory CD8+ T cell survival, promotes clonal expansion, and regulates cytokine release affecting monocyte survival. Soluble CD137 may act as a negative regulator of immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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