Thermo Fisher Scientific Ankyrin B Polyclonal Antibody
Ankyrin B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat 반응성 확인됨. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Ankyrin B (amino acids 1901–2100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the ankyrin family of proteins that link integral membrane proteins to the spectrin-actin cytoskeleton. Ankyrins are crucial for cell motility, activation, proliferation, contact, and maintenance of specialized membrane domains. They typically consist of three structural domains:
- Amino-terminal domain with multiple ankyrin repeats
- Central region containing a conserved spectrin-binding domain
- Carboxy-terminal domain that is regulatory and variable
Ankyrin B is essential for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene are associated with long QT syndrome 4. Multiple transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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