Thermo Fisher Scientific CIITA Polyclonal Antibody

Thermo Fisher Scientific CIITA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

Anti-CIITA antibody is an IgG fraction antibody purified from monospecific antiserum by a multi-step process including delipidation, salt fractionation, and ion exchange chromatography followed by extensive dialysis.
Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified CIITA [Human].
Cross-reactivity against CIITA from other species may occur but has not been specifically determined.

Target Information

CIITA contains an acidic transcriptional activation domain, four leucine-rich repeats (LRRs), and a GTP binding domain. It acts as a positive regulator of class II major histocompatibility complex (MHC) gene transcription and is referred to as the “master control factor” for the expression of these genes.
CIITA binds GTP and uses GTP binding to facilitate its transport into the nucleus. Once in the nucleus, it does not bind DNA but acts via intrinsic acetyltransferase (AT) activity in a coactivator-like manner.
Mutations in this gene have been associated with bare lymphocyte syndrome type II (hereditary MHC class II deficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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