Thermo Fisher Scientific MTM1 Polyclonal Antibody
MTM1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat에서 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human Myotubularin (MTM1, UniProt ID: Q13496-1, amino acids 1–603) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553920 |
Product Specific Information
- Detects endogenous MTM1 protein (~70 kDa).
- Purity >95% by SDS-PAGE.
Target Information
Human MTM1 is a 603-amino-acid protein mutated in myotubular myopathy. The related protein hMTMR2 is associated with a recessive form of Charcot-Marie-Tooth neuropathy.
Myotubularin functions as a lipid phosphatase acting on phosphatidylinositol 3-monophosphate, regulating the PI 3-kinase pathway and membrane trafficking.
Wild-type myotubularin can dephosphorylate PI 3-P and PI 4-P in vitro, reducing PI 3-P levels by down-regulating PI 3-K activity and promoting PI 3-P degradation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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