Thermo Fisher Scientific ORM2 Polyclonal Antibody
Thermo Fisher Scientific ORM2 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 AGP-2 펩타이드에 특이적입니다. Western blot 및 IHC에 적합하며 고순도(>95%)로 정제되었습니다. 연구용으로만 사용되며 염증 관련 단백질 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in human AGP-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553919 |
Product Specific Information
- Detects endogenous protein at molecular weights of 24 and 45 kDa.
- Purity >95% by SDS-PAGE.
Target Information
AGP (α1-acid Glycoprotein) is an acute-phase plasma protein synthesized by the liver. It regulates interactions between blood and endothelial cells and mediates cell extravasation during infection and inflammation. Expression is induced by bacterial lipopolysaccharides.
AGP binds basic drugs with high affinity and low capacity at physiological pH. Human plasma levels range from 0.5–1.4 mg/mL and increase during acute inflammation, making it useful for diagnosing inflammatory conditions.
Multiple AGP genes exist (AGP-1, AGP-2, AGP-3, AGP-8). AGP-1 and AGP-2 contain five and six N-glycosylation sites, respectively. Abnormal AGP-1 expression is linked to sarcoidosis and immunogenetic diseases, while AGP-2 mutations are associated with carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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