Thermo Fisher Scientific FAM111B Polyclonal Antibody
FAM111B 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 인간 FAM111B 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FAM111B. Recombinant protein control fragment (Product # RP-97540) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641223 |
Product Specific Information
Immunogen sequence:
SMKTEENKSF SAMEDDQRTR PEVSKDTVMK QTHADTPVDH CLSGIRKCSS TFKLKSEVNK HETALEMQNP NLNNKECCFT FTLNGNS
Highest antigen sequence identity to the following orthologs:
- Mouse: 27%
- Rat: 24%
Target Information
FAM111B is a 734 amino acid protein encoded by a gene on human chromosome 11, which constitutes about 4% of human genomic DNA and is dense in gene-disease associations. The chromosome 11-encoded ATM gene is important for regulation of cell cycle arrest and apoptosis following double-strand DNA breaks. ATM mutation leads to ataxia-telangiectasia. Blood disorders such as sickle cell anemia and beta-thalassemia are caused by HBB gene mutations. Wilms’ tumors, WAGR syndrome, and Denys-Drash syndrome are associated with mutations in the WT1 gene. Other disorders linked to chromosome 11 defects include Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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