Thermo Fisher Scientific FAM111B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
SMKTEENKSF SAMEDDQRTR PEVSKDTVMK QTHADTPVDH CLSGIRKCSS TFKLKSEVNK HETALEMQNP NLNNKECCFT FTLNGNS

Highest antigen sequence identity to the following orthologs:

• Mouse: 27%
• Rat: 24%

Target Information

FAM111B is a 734 amino acid protein encoded by a gene on human chromosome 11, which constitutes about 4% of human genomic DNA and is dense in gene-disease associations. The chromosome 11-encoded ATM gene is important for regulation of cell cycle arrest and apoptosis following double-strand DNA breaks. ATM mutation leads to ataxia-telangiectasia. Blood disorders such as sickle cell anemia and beta-thalassemia are caused by HBB gene mutations. Wilms’ tumors, WAGR syndrome, and Denys-Drash syndrome are associated with mutations in the WT1 gene. Other disorders linked to chromosome 11 defects include Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.