Thermo Fisher Scientific Human IFN-gamma, Animal-Free Recombinant Protein, PeproTech
인간 IFN-γ 재조합 단백질로, 동물 유래 성분이 없는 고순도 시약입니다. 세포독성 분석 등 기능적 시험에 적합하며, ≥98% 순도와 낮은 엔도톡신 수준을 제공합니다. 면역 반응 연구 및 사이토카인 활성 평가에 활용됩니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (72)
Miscellaneous PubMed (Misc)
- Refer to publications (5)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Bacteria, Fish, Human, Mouse, Rat, Virus |
| Expression System | E. coli |
| Amino acid sequence | MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ |
| Molecular weight | 16.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | < 0.1 EU/µg |
| Activity | ED50 ≤ 0.05 ng/ml (specific activity ≥ 2 × 10⁷ units/mg, HT-29 cytotoxicity assay) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human IFN-gamma is a 16.8 kDa protein containing 144 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor and immune interferon produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin, and other cytokines.
It is a dimeric protein consisting of two 146 amino acid subunits and functions as a homodimer (~45 kDa). On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
The biological activity of IFN gamma is highly species-specific; human IFN gamma does not cross-react with mouse IFN gamma.
Functions include:
- Antiviral activity
- Tumor antiproliferative activity
- Induction of class I and II MHC
- Macrophage activation
- Enhanced immunoglobulin secretion by B lymphocytes
IFN gamma is involved in cytokine regulation and acts synergistically with other cytokines. Activation occurs via IFN gamma receptor I and II, initiating the JAK-STAT pathway.
Human IFN gamma shows about 40% sequence homology with mouse IFN gamma and is upregulated by IL2, FGF basic, EGF, and downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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