Thermo Fisher Scientific Human IL-29 (IFN lambda-1), Animal-Free Recombinant Protein, PeproTech
동물 유래 성분이 없는 재조합 인간 IL-29 (IFN lambda-1) 단백질로 항바이러스 반응 연구에 적합. STAT 인산화를 통한 활성 검증 완료. 고순도(≥98%) 및 낮은 엔도톡신(<0.1 EU/µg). E. coli 발현, 동결건조 형태로 -20°C 보관.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Non-human primate |
| Expression System | E. coli |
| Amino acid sequence | PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST |
| Molecular weight | 19.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <0.1 EU/µg |
| Activity | Activates STAT phosphorylation in ISRE Luciferase Reporter Assay using COLO205 cells (ED50: 0.2–0.5 ng/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human IFN-lambda1 is a 19.8 kDa protein containing 178 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
IFN-lambdas constitute a novel family of interferons that mediate antiviral protection in various cells.
There are three members in this family: lambda1 (IL-29), lambda2 (IL-28A), and lambda3 (IL-28B).
Similar to type I IFNs, IFN-lambdas activate intracellular signaling to promote gene expression.
These cytokines mediate antiviral protection through a class II cytokine receptor complex composed of:
- CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas)
- CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors)
IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells.
Dendritic cells differentiated in response to IFN-lambdas express high levels of MHC class I and II, but low levels of costimulatory molecules.
These cells can induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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