Thermo Fisher Scientific SCN11A (NaV1.9) Polyclonal Antibody

Thermo Fisher Scientific SCN11A (NaV1.9) Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:200
• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL or 0.2 mL double distilled water (DDW), depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels possess two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (α, β, γ). ENaC in kidney, lung, and colon plays a key role in trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
Mutations in ENaC subunits can lead to hypertension (Liddel’s syndrome) or pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: ASC-017-GP200UL_SCN11A_O88457-1_Guinea_pig.svg, ASC-017-GP200UL_SCN11A_O88457-1_Guinea_pig_PDP.jpeg)