Thermo Fisher Scientific NaV1.8 (SCN10A) Polyclonal Antibody, Atto 594

Applications

• Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent

Product Specifications

Product Specific Information

• Reconstitution: 50 µL double distilled water (DDW), depending on sample size
• Ships as lyophilized powder at room temperature
• Upon arrival, store at -20°C
• Reconstituted solution can be stored at 4°C for up to 1 week
• For long-term storage, aliquot and keep at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

Scn10a (NaV1.8) is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability in excitable membranes and plays a role in neuropathic pain mechanisms. Members of the Deg/ENaC superfamily share structural similarities, including two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with conserved cysteine-rich regions. ENaC proteins (α, β, γ isoforms) regulate sodium and fluid balance in kidney, lung, and colon and are involved in aldosterone-dependent sodium reabsorption and blood pressure control. Mutations in SCN10A are associated with Episodic Pain Syndrome, Familial 2, and Sodium Channelopathy-Related Small Fiber Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.