Thermo Fisher Scientific BIKE Polyclonal Antibody
Rabbit polyclonal antibody against human BIKE (BMP2K) 단백질로, IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer에 0.1% sodium azide를 포함하고 있습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from N-terminus of human BMP2K |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550750 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon (100%); Mouse (93%); Chicken, Zebrafish (87%) - Antigen retrieval requires Proteinase K treatment.
Target Information
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis, and apoptosis.
A group of proteins involved in this process are the serine/threonine (Ser/Thr) protein kinases.
BMP2K (BMP2 inducible kinase), also known as BIKE, is a 1,161 amino acid nuclear protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family.
It is thought to be involved in osteoblast differentiation and catalyzes ATP-dependent phosphorylation of bone morphogenic proteins (BMPs), which are essential for proper cartilage and bone formation.
Through its catalytic activity, BMP2K may play a role in signaling pathways that mediate bone growth and cellular differentiation.
Three isoforms of BMP2K exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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