Thermo Fisher Scientific CaV1.2 Polyclonal Antibody
Rabbit polyclonal antibody targeting CaV1.2 (CACNA1C) for IHC(P) applications. Recognizes human protein with high species identity. Unconjugated, antigen affinity purified, liquid form. Ideal for calcium channel research.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from internal region of human CACNA1C / Cav1.2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550756 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gibbon (100%)
- Gorilla, Monkey, Marmoset (94%)
Target Information
CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. These channels mediate calcium ion influx upon membrane polarization. The alpha-1 subunit, composed of 24 transmembrane segments, forms the pore through which ions pass. The calcium channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Multiple isoforms arise from different genes or alternative splicing. The CACNA1C protein binds to and is inhibited by dihydropyridine. Alternative splicing results in various transcript variants encoding distinct proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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