Thermo Fisher Scientific CISD2 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal CISD2 항체. Western blot 및 IHC(P) 적용 가능. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, PBS/glycerol buffer에 저장. 연구용으로 Wolfram syndrome 2 관련 CISD2 단백질 분석에 적합.
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Thermo Fisher Scientific CISD2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CISD2 (Accession Q8N5K1), corresponding to amino acid residues V83–K133 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853976 |
Product Specific Information
Antibody detects endogenous levels of total CISD2.
Target Information
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2.
CISD2 is a zinc finger protein localized to the endoplasmic reticulum and mitochondria, binding an iron/sulfur cluster.
It interacts with Bcl-2 and can be displaced by the BH3-only protein BIK, contributing to the regulation of BIK-initiated autophagy.
CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death and premature aging phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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