Thermo Fisher Scientific IL-22 Polyclonal Antibody, Biotin, PeproTech
Human IL-22 검출용 Biotin-conjugated Rabbit Polyclonal Antibody. Western blot 및 Sandwich ELISA에 최적화되어 있으며, 높은 특이성과 민감도를 제공. 항원 친화 크로마토그래피로 정제된 동결건조 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- 500-P211BT-xxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-22 Polyclonal Antibody, Biotin, PeproTech
Thermo Fisher Scientific IL-22 Polyclonal Antibody, Biotin, PeproTech
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL | - |
| ELISA | 0.25–1.0 µg/mL | 1 publication |
| Miscellaneous PubMed | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Recombinant Human IL-22 |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 0.1–1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
| RRID | AB_2929835 |
Product Specific Information
AA Sequence of recombinant protein:
MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
Preparation:
Produced from sera of rabbits immunized with highly pure recombinant Human IL-22. Anti-Human IL-22-specific antibody purified by affinity chromatography and biotinylated.
Sandwich ELISA:
To detect Human IL-22 by sandwich ELISA (using 100 µL/well), use 0.25–1.0 µg/mL of this antibody. In conjunction with PeproTech Polyclonal Anti-Human 4-1BBL (500-P211) as a capture antibody, enables detection of at least 0.2–0.4 ng/well of recombinant Human IL-22.
Western Blot:
To detect Human IL-22 by Western Blot, use 0.1–0.2 µg/mL. With compatible reagents, detection limit is 1.5–3.0 ng/lane under reducing or non-reducing conditions.
Package Information:
500-P211BT-1MG is provided as 2 × 500 µg.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family (including IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I/II interferons).
Produced mainly by activated T cells and NK cells, the IL-22 gene is located on chromosome 12q and structurally related to IL-10.
IL-22 interacts with a receptor complex of IL-22R1 and IL-10R2, activating JAK-STAT signaling. A soluble receptor, IL-22BP, can antagonize IL-22 signaling.
IL-22 targets nonimmune cells such as skin, digestive, respiratory cells, hepatocytes, and keratinocytes.
It functions as an effector cytokine of the Th17 lineage, regulating innate immunity genes in skin and promoting wound healing responses.
IL-22 is upregulated during chronic inflammation and essential for defense against extracellular pathogens.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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