Thermo Fisher Scientific Arginase 1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1125, ARG1/1126)
인간 Arginase 1을 인식하는 단클론 항체로 간세포암종(HCC) 표지자로 활용 가능. IHC(P) 및 IHC(PFA) 적용, 고순도 Protein A/G 정제. 4°C 보관, 진단용이 아닌 연구용 시약.
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- 383-MSM3-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Arginase 1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/1125, ARG1/1126)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ARG1/1125, ARG1/1126 |
| Immunogen | Recombinant human ARG1 protein fragment (around aa11–97) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are crucial for cell proliferation and detoxification. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, it is expressed in blood neutrophils but not CCR3+ granulocytes. In mice, Arginase 1 marks alternatively activated macrophages (M2a).
Arginase-1 is typically found in myeloid cells infiltrating tumors and in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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