Thermo Fisher Scientific Arginase 1 (Hepatocellular Carcinoma Marker) Recombinant Rabbit Monoclonal Antibody (ARG1/6790R)

Applications

Western Blot (WB)

• Tested Dilution: 2–4 µg/mL

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 2–4 µg/mL

Product Specifications

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are crucial for cell proliferation and detoxification from protein degradation. By degrading arginine, Arginase 1 reduces nitric oxide synthesis by depriving NO synthase of its substrate.

In humans and mice, Arginase 1 is expressed in liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(해당 이미지 파일: Arginase_1_P05089-1_Rabbit.svg, Arginase_1_P05089-1_Rabbit_PDP.jpeg)