Thermo Fisher Scientific Phospho-KCNH2 (Ser1137) Polyclonal Antibody
KCNH2 단백질의 Ser1137 인산화 부위를 인식하는 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 사용 가능. 사람, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용 전용 시약.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNH2 (Accession Q12809), corresponding to amino acid residues around phosphorylated Ser1137. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816743 |
Product Specific Information
This antibody detects endogenous levels of KCNH2 only when phosphorylated at Ser1137.
Target Information
The human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG: the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1 alpha. Residues within the C-terminal region play a role in channel expression and gating, including voltage-dependent activation. HERG is expressed in the heart, predominantly in the ventricles. Mutations in HERG can increase beat-to-beat variability and early after depolarization, contributing to arrhythmogenic conditions such as long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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