Thermo Fisher Scientific Phospho-KV1.1 (KCNA1) (Ser446) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human KCNA1(Accession Q09470), corresponding to amino acid residues around phosphorylated Ser446. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:KV1.1 (KCNA1),uniProtId:Q09470-1,ncbiNodeId:9606,antigenRange:446,antigenLength:495,antigenImageFileName:PA5-105318_KV1.1_KCNA1_Q09470-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105318_KV1.1_KCNA1_Q09470-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816746

Product Specific Information

Antibody detects endogenous levels of KCNA1 only when phosphorylated at Ser446.

Target Information

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.