Thermo Fisher Scientific Phospho-KV1.1 (KCNA1) (Ser446) Polyclonal Antibody
KCNA1 단백질의 Ser446 위치에서 인산화된 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, 1 mg/mL 농도의 액상 형태로 제공. 인간 시료 반응성, PBS 및 글리세롤 기반 저장용액 포함.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNA1 (Accession Q09470), corresponding to amino acid residues around phosphorylated Ser446 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816746 |
Product Specific Information
Antibody detects endogenous levels of KCNA1 only when phosphorylated at Ser446.
Target Information
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel.
The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif.
The functional channel is a homotetramer. The N-terminus associates with beta subunits that can modify inactivation properties and expression levels.
The C-terminus complexes with a PDZ domain protein responsible for channel targeting.
Mutations in this gene have been associated with myokymia with periodic ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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