Thermo Fisher Scientific PSMD14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PSMD14 for WB and IP applications. Recognizes residues 260–310 of the 26S proteasome subunit. Supplied as a 1 mg/mL liquid, unconjugated form. Recommended storage at 4°C and shelf life of 1 year.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 260 and 310 of Human Proteasome (Prosome, Macropain) 26S Subunit, non-ATPase, 14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast), a subunit of the 19S complex, is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn²⁺-dependent protease, unlike other deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs and ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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