Thermo Fisher Scientific PSME1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:5,000
• Immunoprecipitation (IP): 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from the date of receipt.

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most proteins in the eukaryotic cytosol and nucleus, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit complex (~2.5 MDa) composed of a 20S core and 19S regulatory subunits, which recognize ubiquitinated proteins and facilitate their degradation.
Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.