Thermo Fisher Scientific KCNMB1 Polyclonal Antibody
Rabbit에서 생산된 KCNMB1 단클론 항체로 Western blot 및 ELISA에 사용 가능. 인간 단백질에 반응하며, 액상 형태로 제공됨. 친화 크로마토그래피로 정제되었으며 -20°C에서 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 30–102 of human KCNMB1 (NP_0041281) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.21 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804369 |
Product Specific Information
- Immunogen sequence: TYYILVTTVL PLYQKSVWTQ ESKCHLIETN IRDQEELKGK KVPQYPCLWV NVSAAGRWAV LYHTEDTRDQ NQQ
- Positive Samples: U-87MG, THP-1, BxPC-3
- Cellular Location: Membrane, Multi-pass membrane protein
Target Information
Potassium channels are ubiquitously expressed proteins functioning in both excitable and non-excitable cells. The large conductance, calcium-activated potassium channel (Maxi K+) is unique in being activated by both intracellular calcium increases and membrane depolarization.
The Maxi K+ alpha homotetramer contains voltage sensor and calcium binding domains. In vascular smooth muscle, a beta-subunit associates in a 1:1 ratio, reducing the calcium concentration needed to open the pore by 5–10 fold.
Maxi K+ beta-subunits are potential therapeutic targets due to their role in blood flow and blood pressure regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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