Thermo Fisher Scientific Granzyme K Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 27-264 of human GZMK (NP_0020951) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Granzyme K,uniProtId:P49863-1,ncbiNodeId:9606,antigenRange:27-264,antigenLength:264,antigenImageFileName:PA5-87719_Granzyme_K_P49863-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87719_Granzyme_K_P49863-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.06 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804366

Product Specific Information

Immunogen sequence: IIGGKEVSPH SRPFMASIQY GGHHVCGGVL IDPQWVLTAA HCQYRFTKGQ SPTVVLGAHS LSKNEASKQT LEIKKFIPFS RVTSDPQSND IMLVKLQTAA KLNKHVKMLH IRSKTSLRSG TKCKVTGWGA TDPDSLRPSD TLREVTVTVL SRKLCNSQSY YNGDPFITKD MVCAGDAKGQ KDSCKGDSGG PLICKGVFHA IVSGGHECGV ATKPGIYTLL TKKYQTWIKS NLVPPHTN; Positive Samples: Mouse liver, Rat liver; Cellular Location: Cytoplasmic granule

Target Information

Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.