Thermo Fisher Scientific Phospho-DNA-PK (Ser2056) Polyclonal Antibody
DNA 손상 반응 연구용 Rabbit Polyclonal 항체로, Ser2056 인산화 부위에 특이적으로 결합합니다. IHC(P) 및 peptide-ELISA에 적합하며, 고순도 액상 형태로 -20°C 보관. Thermo Fisher Scientific 제공.
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Thermo Fisher Scientific Phospho-DNA-PK (Ser2056) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Peptide-ELISA (pep-ELISA) | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human DNA-PK around the phosphorylation site of Ser2056 (Y-S-SP-Q-D) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555078 |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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