Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI14F10), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Pellino proteins are a family of E3 ubiquitin ligases acting as upstream mediators in Toll-like receptor (TLR) pathways, leading to activation of MAP kinases and transcription factors.
Pellino 1 is essential for interleukin-1-mediated signaling through interaction with the IRAK4–IRAK–TRAF6 complex, resulting in NF-κB activation.
Like other Pellino family members, Pellino 1 catalyzes polyubiquitination of IRAK1 and is activated via phosphorylation by IRAK1, IRAK4, IKK-ε, or TBK1.
Its activity is further regulated by ubiquitination and sumoylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.