Thermo Fisher Scientific TDP-43 Recombinant Rabbit Monoclonal Antibody (JM51-10)
TDP-43 단백질을 표적하는 재조합 토끼 단일클론 항체로, 높은 특이성과 일관된 로트 간 품질을 제공합니다. Western blot, IHC, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫, 제브라피쉬 반응성.
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Thermo Fisher Scientific TDP-43 Recombinant Rabbit Monoclonal Antibody (JM51-10)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:250–1:500 | View 1 publication |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM51-10 |
| Immunogen | Synthetic peptide within Human TDP43 aa 354–390 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809904 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select optimal candidates.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
TDP43 was initially identified as a cellular protein binding to HIV-1 TAR DNA motifs, acting as a transcriptional repressor of the HIV-1 LTR. It also regulates splicing of exon 9 in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, likely through UG repeat association at the splice site.
Pathologic TDP43, a hyperphosphorylated, ubiquitinated, and cleaved form, is a major disease protein in frontotemporal dementia (FLTD-U).
TDP43 is distinct from TRBP1, an RNA-binding protein that interacts with HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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