Thermo Fisher Scientific Aromatase Recombinant Rabbit Monoclonal Antibody (JM10-68)
인체 및 랫드 시료에 반응하는 Aromatase 단백질 검출용 재조합 토끼 단클론 항체. Western blot 및 면역침강(IP)에 적합하며 높은 특이성과 재현성을 제공. 단백질 A 정제, 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM10-68 |
| Immunogen | Synthetic peptide within Human Aromatase aa 23–63 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809905 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
Aromatase localizes to the endoplasmic reticulum and catalyzes the final steps of estrogen biosynthesis through three successive hydroxylations of the A ring of androgens.
Mutations in this gene may lead to increased or decreased enzyme activity, affecting estrogen-related physiological functions. Two transcript variants are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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