Thermo Fisher Scientific STAM1, 2 Polyclonal Antibody
STAM1 및 STAM2 단백질을 인식하는 Thermo Fisher Scientific의 양친매성 항체로, 인간, 생쥐, 랫트에서 반응합니다. Western blot 및 IHC에 적합하며, 합성 펩타이드 면역원으로 제작되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific STAM1, 2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 300–360 of the internal part of human STAM1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in many species including rat, mouse, zebra fish, and xenopus.
- Specificity: STAM1 and STAM2.
Target Information
STAM1:
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSF stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play roles in endocytic trafficking and T-cell development.
Subunit: Heterodimer composed of STAM1 and HGS/HRS. Interacts with STAMBP/AMSH.
Tissue Specificity: Ubiquitously expressed.
STAM2:
Participates in intracellular signal transduction mediated by cytokines and growth factors, likely through association with ubiquitinated cargo proteins on the early endosome. Plays a role in sorting for lysosomal trafficking and T-cell development.
Subunit: Heterodimer or heterotrimer composed of STAM2 and HGS/Hrs; EPS15 may be part of the complex. Interacts with STAMBP/AMSH, JAK2, JAK3, USP8/UBPY, CBX5, and VPS37C.
Tissue Specificity: Ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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