Thermo Fisher Scientific SCNEA Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Publications

• Miscellaneous PubMed (Misc): 1 publication available

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• Specificity: SCNN1A

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels possess two short intracellular amino and carboxyl termini, two short membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC: alpha, beta, and gamma. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure. ENaC is thought to be regulated through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel.
Gain-of-function mutations in beta or gamma ENaC can cause severe arterial hypertension (Liddel’s syndrome), while loss-of-function mutations in alpha or beta ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.