Thermo Fisher Scientific Neurokinin B receptor Polyclonal Antibody
Rabbit polyclonal antibody targeting human Neurokinin B receptor (NK3R). Validated for WB and IHC applications. Lyophilized form, unconjugated, stored at 4°C or -20°C. Suitable for research use in neurobiology and receptor signaling studies.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from amino acid region 400–450 of human Neurokinin B receptor conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Neurokinin B receptor.
Target Information
The tachykinins are a family of small peptides including the neurotransmitters substance P, neurokinin A, and neurokinin B. These peptides act on three distinct seven-transmembrane G-protein coupled receptors at different concentrations.
The NK-3 receptor (NK3R) has the highest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, leading to release of vasopressin and oxytocin.
NK3R may play a role in learning and memory, as mice lacking this gene show cognitive deficits. Although NK3R has been suggested to regulate vagal afferent relay neurons, it is more likely activated by substance P or neurokinin A, since airway nerves do not express neurokinin B.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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