Thermo Fisher Scientific NMDAR3A Polyclonal Antibody
Rabbit polyclonal antibody targeting NMDAR3A (Grin3a) for WB and IHC applications. Recognizes mouse and rat species. Lyophilized form, reconstitute with sterile water. Suitable for studying NMDA receptor signaling and synaptic development.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1091–1135 of rat NMDAR3A conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and shares 92% identity with the human sequence.
- Specificity: NMDAR3A.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels characterized by reduced single-channel conductance, low calcium permeability, and low voltage-dependent sensitivity to magnesium. It is mediated by glycine and may play a role in the development of dendritic spines and PPP2CB-NMDAR mediated signaling mechanisms.
Grin3a belongs to the superfamily of glutamate-regulated ion channels and participates in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in knockout mice deficient in Grin3a suggest involvement in synaptic element development by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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