Thermo Fisher Scientific Fibronectin Polyclonal Antibody
Fibronectin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Affinity Chromatography로 정제된 고품질 항체입니다. 세포외기질 및 분비 단백질 연구에 활용됩니다.
- 카탈로그번호
- PA5120475
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1000–1:6000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2205–2477 of human Fibronectin (NP_9976472) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.74 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914047 |
Product Specific Information
- Positive test controls: U-87MG, NIH/3T3
- Subcellular localization: Secreted, extracellular matrix, extracellular space
Immunogen sequence:
EALSQTTISW APFQDTSEYI ISCHPVGTDE EPLQFRVPGT STSATLTGLT RGATYNVIVE ALKDQQRHKV REEVVTVGNS VNEGLNQPTD DSCFDPYTVS HYAVGDEWER MSESGFKLLC QCLGFGSGHF RCDSSRWCHD NGVNYKIGEK WDRQGENGQM MSCTCLGNGK GEFKCDPHEA TCYDDGKTYH VGEQWQKEYL GAICSCTCFG GQRGWRCDNC RRPGGEPSPE GTTGQSYNQY SQRYHQRTNT NVNCPIECFM PLDVQADRED SRE
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also present as a soluble plasma protein.
Fibronectin contains repeating modules forming domains that interact with collagen, heparin, and cell receptors such as integrins. It plays a key role in cell adhesion, migration, wound healing, coagulation, host defense, and metastasis. Increased Fibronectin expression is associated with non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis. The gene encoding Fibronectin undergoes alternative splicing, producing up to 20 transcript variants, though not all full-length forms are characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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