Thermo Fisher Scientific MYLK Polyclonal Antibody, Biotin
MYLK 단백질을 표적으로 하는 Biotin 결합 다클론 항체로, Western blot, IHC, ELISA, IP 등 다양한 실험에 사용 가능. Human, Mouse, Rat 반응성. Chicken IgY 기반으로 높은 특이성과 안정성 제공. 연구용으로만 사용.
- 카탈로그번호
- MYLK-Y-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1870–1917 on human Myosin light chain kinase, smooth muscle isoform 1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains, enabling contractile activity through myosin-actin interaction. It regulates smooth muscle contraction, vascular permeability, and tissue edema formation. In the nervous system, MLCK influences astrocytic process growth and neurotransmitter release. It also plays a role in fibroblast apoptosis signaling. Various isoforms, including smooth muscle and non-muscle types, are expressed across adult and fetal tissues. The Telokin isoform binds calmodulin and is widely distributed. MLCK activity may be down-regulated by phosphorylation and the protein includes one fibronectin type III domain and nine immunoglobulin-like C2-type domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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