Thermo Fisher Scientific Human Activin A Recombinant Protein

Thermo Fisher Scientific Human Activin A Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-75635 contains a purified 116 amino acid fragment (aa311–426) corresponding to the mature Inhibin beta A chain protein with an N-terminal hexahistidine tag.
RP-75635 may be used as a positive control in Western blot assays.

Target Information

Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
They signal through a heteromeric complex of receptor serine kinases including at least two type I (I and IB) and two type II (II and IIB) receptors. These transmembrane proteins possess a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serine/threonine specificity.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Activin A mutations are associated with fibrodysplasia ossificans progressive.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.