Thermo Fisher Scientific Human Activin A Recombinant Protein
Human Activin A 재조합 단백질로 Western blot 등 연구용에 적합. E. coli 발현 시스템에서 생산된 고순도 His-tag 단백질. 116 아미노산 길이의 Inhibin beta A 체인 단편 포함. TGF-beta 신호전달 연구에 활용 가능.
- 카탈로그번호
- RP75635
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human Activin A Recombinant Protein
Applications
- Western Blot (WB): Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Amino acids Gly311–Ser426 containing an N-terminal His-tag |
| Tag | His-tag |
| Molecular Weight | 17.47 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Purified |
| Storage Buffer | Laemmli, pH 6.8 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
RP-75635 contains a purified 116 amino acid fragment (aa311–426) corresponding to the mature Inhibin beta A chain protein with an N-terminal hexahistidine tag.
RP-75635 may be used as a positive control in Western blot assays.
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
They signal through a heteromeric complex of receptor serine kinases including at least two type I (I and IB) and two type II (II and IIB) receptors. These transmembrane proteins possess a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serine/threonine specificity.
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Activin A mutations are associated with fibrodysplasia ossificans progressive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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