Thermo Fisher Scientific Human IL-12 p40 Recombinant Protein
Recombinant human IL-12 p40 protein with N-terminal His-tag. Used as a positive control in immunological assays. Expressed in E. coli and purified to >95% by SDS-PAGE. Supplied in liquid form with storage buffer at -20°C.
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Applications
Western Blot (WB)
- Assay-dependent
Control (Ctrl)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Ile23–Ser328 containing an N-terminal His-tag |
| Tag | His-tag |
| Molecular Weight | 39.2 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >95%, by SDS-PAGE under reducing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Purification | Purified |
| Storage Buffer | 25 mM sodium phosphate, pH 7.0, with 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This product contains purified recombinant human IL-12 p40 protein with an N-terminal hexahistidine tag.
It may be used as a positive control in various immunological assays.
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells and has diverse biological activities.
Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa cytokine receptor-like subunit encoded by this gene and a 35 kDa subunit encoded by IL12A.
This cytokine is expressed by activated macrophages and is essential for Th1 cell development. It helps maintain memory/effector Th1 cells for long-term protection against intracellular pathogens.
Overexpression of IL12B has been observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role in disease pathogenesis.
Promoter polymorphisms of IL12B are associated with the severity of atopic and non-atopic asthma in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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