Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/3569)

Applications

Product Specifications

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodeling and also found as a soluble plasma protein.

Fibronectin consists of repeating modules forming domains that interact with itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a key role in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis. Elevated fibronectin expression is associated with carcinoma development, particularly in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents.

The fibronectin gene undergoes alternative splicing in three regions, potentially producing up to 20 transcript variants, though some full-length variants remain undetermined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.