Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/3569)
Human fibronectin 단백질을 인식하는 마우스 단클론 항체로, IHC, ELISA, Peptide Array 등 다양한 응용에 사용 가능. Recombinant fragment(aa 467-595)를 면역원으로 제작되었으며, Protein A/G 정제 및 무보존제 PBS 용액 형태로 제공. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FN1/3569 |
| Immunogen | Recombinant fragment (around aa 467–595) of human fibronectin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also circulates as a soluble plasma protein.
Fibronectin is composed of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell surface receptors (e.g., integrins). It plays key roles in cell adhesion, migration, wound healing, blood coagulation, host defense, and metastasis. Elevated fibronectin expression, particularly in non-small cell lung carcinoma, is associated with enhanced tumorigenicity and resistance to chemotherapy-induced apoptosis. The fibronectin gene undergoes alternative splicing, potentially generating up to 20 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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