Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI6F5), TrueMAB

Applications

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to reach a final concentration of about 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

T lymphocytes initiate cell-mediated immune responses when stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 interacts with ligands PDL-1 and PDL-2, transmitting inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS).
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.